Maximum listening speeds for the blind

Proceedings of the 9th International Conference on Auditory Display (ICAD), Boston, MA, July 7-9, 2003.Blind people usually use voice output using a computer, however, there is little objective data about how fast or accurately they can obtain information in a fixed amount of time In this paper, we describe the highest and the most suitable listening rate for the blind based on our human factors experiments, aiming at producing a kind of indicator for use by developers. We experimented with the highest and the most suitable listening rates for blind users with objective and subjective test methods. The results showed that the advanced blind testers could listen to the spoken material at speeds 1.6 times faster than the highest rate of the tested TTS (Text-to- Speech) engine. This indicates that the currently available TTS engines should support faster rates. It also showed that the highest rate often changes depending on the difficulty of the sentences and words. These results would be valuable and useful indicators for developers to design applications for the blind and to improve the nonvisual user interfaces

Multiple inflammatory cytokine-productive ThyL-6 cell line established from a patient with thymic carcinoma

Thymic epithelial cells can produce many kinds of cytokines, and interleukin (IL)-6-producing thymic carcinoma cases have been reported. However, a cytokine-producing human thymic tumor cell line has not previously been established. In this paper, we report a novel, multiple inflammatory cytokine-productive cell line that was established from a patient with thymic carcinoma. This cell line, designated ThyL-6, positively expressed epithelial membrane antigen, cytokeratins, vimentin intermediate filament and CD5, although hematological markers were not present in the cells. Cytokine antibody array analysis showed that the cells secreted several cytokines including IL-1α, IL-6, IL-8, RANTES, soluble TNFα-receptor 1, VEGF and CTLA into the culture medium. The addition of ThyL-6-cultured supernatant supported the growth of human myeloma ILKM-3 cells, which require the presence of IL-6 in the culture medium for the maintenance of cell growth, suggesting that the secreted IL-6 from ThyL-6 cells was biologically active. Chromosome analysis demonstrated that ThyL-6 cells had complex karyotype anomalies, including der(16)t(1;16); the latter has been recognized in thymic squamous cell carcinoma and thymic sarcomatoid carcinoma cases, as well as in several other kinds of malignancies. Heterotransplantation of the cells into nude mice showed tumorigenesis with neutrophil infiltration and liquefactive necrosis. These findings suggest that ThyL-6 cells will provide us with a new experimental tool for investigating not only the pathogenesis, biological behavior, chromo-somal analysis and therapeutic reagents of human thymic carcinoma, but also for studying cytokine-chemokine network systems

Screening of bacterial DNA in bile sampled from healthy dogs and dogs suffering from liver- or gallbladder-associated disease

Although the biliary system is generally aseptic, gallbladder microbiota has been reported in humans and some animals apart from dogs. We screened and analyzed the bacterial deoxyribonucleic acid in canine gallbladders using bile sampled from 7 healthy dogs and 52 dogs with liver- or gallbladder-associated disease. PCR screening detected bacteria in 17.3% of diseased dogs (9/52) and none in healthy dogs. Microbiota analysis of PCR-positive samples showed that the microbial diversity differed between liver- and gallbladder-associated disease groups. Thus, a specific bacterial community appears to occur at a certain frequency in the bile of diseased dogs

Breaking The Exclusionary Boundary Between User Experience And Access: Steps Toward Making UX Inclusive Of Users With Disabilities

This research paper points out that we as Designers have failed to come up with a model of UX that would proximate a satisfying user experience for users with disabilities. It underscores the gaps in designer knowledge about disabled bodies. The research paper also draws the attention of the designer community to the limited understanding we presently possess of the disabled people\u27s notions of, and expectations from, satisfying user experiences. It proposes a multi-step process for shifting the focus of design activity from a medical model of accessibility design that retrofits normative designs to the needs of users with disabilities to developing an accessible user experience model (AUX) of design that counts these users as design collaborators, possessors of special knowledge about disabled bodies, and untapped sources of innovative designs that might offer additional design features for all users